Retinopathy, histidine-rich protein-2 and perfusion pressure in cerebral malaria
نویسندگان
چکیده
1 Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi 2 Department of Eye and Vision Science, University of Liverpool, UK 3 St. Paul’s Eye Unit, Royal Liverpool University Hospital, Liverpool, UK 4 College of Medicine, University of Malawi, Blantyre, Malawi 5 Blantyre Malaria Project, Blantyre, Malawi 6 Department of Osteopathic Medical Specialities, Michigan State University, Michigan, USA 7 Department of Pathology and Laboratory Medicine, Vancouver General Hospital, British Columbia, Canada 8 Liverpool School of Tropical Medicine, Liverpool, UK 9 Department of Ophthalmology, University of Edinburgh, Edinburgh, UK 10 Princess Alexandra Eye Pavilion, Edinburgh, UK
منابع مشابه
Value of Plasmodium falciparum Histidine-Rich Protein 2 Level and Malaria Retinopathy in Distinguishing Cerebral Malaria From Other Acute Encephalopathies in Kenyan Children
BACKGROUND The diagnosis of cerebral malaria is problematic in malaria-endemic areas because encephalopathy in patients with parasitemia may have another cause. Abnormal retinal findings are thought to increase the specificity of the diagnosis, and the level of histidine-rich protein 2 (HRP2) may reflect the parasite biomass. METHODS We examined the retina and measured plasma HRP2 levels in c...
متن کاملPlasma concentrations of parasite histidine-rich protein 2 distinguish between retinopathy-positive and retinopathy-negative cerebral malaria in Malawian children.
BACKGROUND Brain histology and ophthalmoscopy suggest that approximately 25% of children with World Health Organization-defined cerebral malaria (CM) have a nonmalarial cause of death. Misclassification complicates clinical care, confounds studies of association, and may obfuscate successes in malaria control. Retinopathy predicts intracerebral parasite sequestration with >90% sensitivity and s...
متن کاملPlasmodium falciparum Histidine-Rich Protein-2 Plasma Concentrations Are Higher in Retinopathy-Negative Cerebral Malaria Than in Severe Malarial Anemia
BACKGROUND Malaria retinopathy has been proposed as marker of "true" cerebral malaria (CM), ie, coma due to Plasmodium falciparum vs coma due to other causes, with incidental P falciparum parasitemia. Plasma P falciparum histidine-rich protein-2 (PfHRP2) concentrations distinguish retinopathy-positive (RP) from retinopathy-negative (RN) CM but have not been compared between RN CM and other form...
متن کاملPlasma Plasmodium falciparum Histidine-Rich Protein-2 Concentrations Are Associated with Malaria Severity and Mortality in Tanzanian Children
Plasma Plasmodium falciparum histidine-rich protein-2 (PfHRP-2) concentrations, a measure of parasite biomass, have been correlated with malaria severity in adults, but not yet in children. We measured plasma PfHRP-2 in Tanzanian children with uncomplicated (n = 61) and cerebral malaria (n = 45; 7 deaths). Median plasma PfHRP-2 concentrations were higher in cerebral malaria (1008 [IQR 342-2572]...
متن کاملAccurate diagnosis of cerebral malaria: a role for parasite histidine-rich protein 2?
The World Health Organization (WHO) definition of cerebral malaria requires Plasmodium falciparum parasitemia and coma not attributable to convulsions, sedatives, hypoglycemia, or another detectable nonmalarial cause [1]. In a series of elegant autopsy-based studies, Taylor and colleagues demonstrated that as many as 23% of children who meet this WHO definition of cerebral malaria actually die ...
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